DNA DAMAGE BINDING PROTEIN2 Shapes the DNA Methylation Landscape
نویسندگان
چکیده
منابع مشابه
Nontarget DNA binding shapes the dynamic landscape for enzymatic recognition of DNA damage
The DNA repair enzyme human uracil DNA glycosylase (UNG) scans short stretches of genomic DNA and captures rare uracil bases as they transiently emerge from the DNA duplex via spontaneous base pair breathing motions. The process of DNA scanning requires that the enzyme transiently loosen its grip on DNA to allow stochastic movement along the DNA contour, while engaging extrahelical bases requir...
متن کاملDNA Damage, Homology-Directed Repair, and DNA Methylation
To explore the link between DNA damage and gene silencing, we induced a DNA double-strand break in the genome of Hela or mouse embryonic stem (ES) cells using I-SceI restriction endonuclease. The I-SceI site lies within one copy of two inactivated tandem repeated green fluorescent protein (GFP) genes (DR-GFP). A total of 2%-4% of the cells generated a functional GFP by homology-directed repair ...
متن کاملDNA Methylation and Its Role in the Development of Leukemia
Epigenetic changes play an essential role in cancer pathogenesis. It has been established by next-generation sequencing that more than 50% of the human cancers carry mutations in mechanisms involved in the organization of the chromatin and epigenetic regulations. DNA methylation is among the most common epigenetic changes in leukemia. In contrast to DNA mutations which are passively inherited f...
متن کاملCorrection: DNA Damage, Homology-Directed Repair, and DNA Methylation
[This corrects the article DOI: 10.1371/journal.pgen.0030110.].
متن کاملThe role and importance of DNA methylation in spermatogenesis process
Background: DNA methylation is one of the epigenetic marks that are created by de novo DNA methylation and be maintained through cell division. This process is catalyzed by DNA methyltransferases. DNA methylation establishment in germ line is important, since they have the potential to regulate gene expression in offspring and improper DNA methylation patterns in germ lines has serious conseque...
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ژورنال
عنوان ژورنال: The Plant Cell
سال: 2016
ISSN: 1040-4651,1532-298X
DOI: 10.1105/tpc.16.00474